September 23, 2017

Comparison of the Performance of Skin Prick, ImmunoCAP, and ISAC Tests in the Diagnosis of Patients with Allergy




Griffiths R.L.M. · El-Shanawany T. · Jolles S.R.A. · Selwood C. · Heaps A.G. · Carne E.M. · Williams P.E. 
Abstract
Background: Allergy is diagnosed from typical symptoms, and tests are performed to incriminate the suspected precipitant. Skin prick tests (SPTs) are commonly performed, inexpensive, and give immediate results. Laboratory tests (ImmunoCAP) for serum allergen-specific IgE antibodies are usually performed more selectively. The immuno-solid phase allergen chip (ISAC) enables testing for specific IgE against multiple allergen components in a multiplex assay.

Dr. Robbie Pesek Discusses Food allergy diagnosis and management


Dr. Robbie Pesek Discusses Food allergy diagnosis and management.

Dr. Phil Lieberman discusses the diagnosis and management anaphylaxis

Dr. Phil Lieberman discusses the diagnosis and management anaphylaxis

September 22, 2017

The impact of 10-valent and 13-valent pneumococcal conjugate vaccines on hospitalization for pneumonia in children: A systematic review and meta-analysis

Elsevier

Vaccine

Available online 11 September 2017
Vaccine
Review
Under a Creative Commons license
open access

Highlights
• Since 2010, PCV10 and PCV13 became available for use in children. 
• This meta-analysis assessed the impact PCV10 and PCV13 in pneumonia hospitalization among children. 
• Novel PCVs reduced hospitalization for pneumonia in children 
• Reduction was more pronounced for radiologically confirmed pneumonia with respect to clinically confirmed pneumonia. 
• None of the studies included in this meta-analysis had been designed to directly compare the impact of PCV10 and PCV13.

September 18, 2017

September 17, 2017

Abridged version of the AWMF guideline for the medical clinical diagnostics of indoor mould exposure

Logo of springeropenLink to Publisher's site
Allergo Journal International
. 2017; 26(5): 168–193.
Published online 2017 Feb 28. doi:  10.1007/s40629-017-0013-3
PMCID: PMC5533814
S2K Guideline of the German Society of Hygiene, Environmental Medicine and Preventive Medicine (GHUP) in collaboration with the German Association of Allergists (AeDA), the German Society of Dermatology (DDG), the German Society for Allergology and Clinical Immunology (DGAKI), the German Society for Occupational and Environmental Medicine (DGAUM), the German Society for Hospital Hygiene (DGKH), the German Society for Pneumology and Respiratory Medicine (DGP), the German Mycological Society (DMykG), the Society for Pediatric Allergology and Environmental Medicine (GPA), the German Federal Association of Pediatric Pneumology (BAPP), and the Austrian Society for Medical Mycology (ÖGMM)
Abstract
This article is an abridged version of the AWMF mould guideline “Medical clinical diagnostics of indoor mould exposure” presented in April 2016 by the German Society of Hygiene, Environmental Medicine and Preventive Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin, GHUP), in collaboration with the above-mentioned scientific medical societies, German and Austrian societies, medical associations and experts.

DRESS: What does the emergency physician need to know?

Authors: Matthew Nemero, DO (Resident Physician, SAUSHEC) and Joshua Oliver, MD (EM Attending Physician, SAUSHEC) // Edited by: Alex Koyfman, MD (@EMHighAK) and Brit Long, MD (@long_brit)
Case
A 15-year-old male patient presents to your emergency department with his family complaining of a fever for 3 days and a rash that started on his face and chest that has been spreading for 3 days. Past medical history is significant for 3 ED visits in the past 90 days and a new diagnosis of epilepsy for which he recently started seeing a neurologist and was placed on phenytoin 3 weeks ago.
Vitals: HR 84, BP 122/74, RR 12, T 38.8 (101.8F), SpO2 99% RA
  • On physical exam, you palpate enlarged and tender cervical and axillary lymph nodes.
  • You note the generalized rash shown below. It does not involve the oral mucosa.

James Verbsky, MD, PhD describes the uses of flow cytometry for the diagnosis of primary immunodeficiency.



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