December 4, 2017

A pilot study with early adolescents: dealing with diet, tobacco and air pollution using practical experiences and biological markers

Open Access
  • Chiara Marabelli,
  • Elena MunariniEmail authorView ORCID ID profile,
  • Micaela Lina,
  • Roberto Mazza,
  • Roberto Boffi,
  • Cinzia De Marco,
  • Ario Ruprecht,
  • Giorgia Angellotti,
  • Chiara Veronese,
  • Paolo Pozzi,
  • Eleonora Bruno,
  • Giuliana Gargano,
  • Adalberto Cavalleri,
  • Giulia Garrone and
  • Franco Berrino
Multidisciplinary Respiratory Medicine201712:30

Abstract
Background: Tobacco use and the Western diet are two of the most important and investigated topics in relation to adolescents’ health. In addition, air pollution is a crucial subject for future generations. School is a key social environment that should promote healthy behaviors in children and adolescents. In this field many different programs have been conducted, with mixed results and effectiveness. Research data suggest that comprehensive and multicomponent approaches may have a greater effect on tobacco use and diet, especially when integrated into a community-wide approach.

November 29, 2017

Adverse drug reactions of montelukast in children and adults



Authors

  • Principal Investigator: Tjalling W de Vries MD PhD
Abstract
Montelukast, a selective leukotriene receptor antagonist, is recommended in guidelines for the treatment of asthma in both children and adults. However, its effectiveness is debated, and recent studies have reported several adverse events such as neuropsychiatric disorders and allergic granulomatous angiitis.

November 20, 2017

Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis

Mirabelli C, Scheers E and Neyts J. Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved]F1000Research 2017, 6(F1000 Faculty Rev):1860 (doi: 10.12688/f1000research.11978.1)
Abstract
Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma and COPD and we discuss the current and potential future treatments. We propose that, in order to prevent exacerbations, the design of novel therapeutics should focus on directly acting antivirals but also include the design of drugs that simultaneously inhibit viral replication and alleviate symptoms of asthma and COPD.

November 18, 2017

Virus-triggered exacerbation in allergic asthmatic children: neutrophilic airway inflammation and alteration of virus sensors characterize a subgroup of patients

 
OPEN ACCESS
  • Antoine DeschildreEmail author,
  • Muriel Pichavant,
  • Ilka Engelmann,
  • Carole Langlois,
  • Elodie Drumez,
  • Guillaume Pouessel,
  • Sophie Boileau,
  • David Romero-Cubero,
  • Irina Decleyre-Badiu,
  • Anny Dewilde,
  • Didier Hober,
  • Véronique Néve,
  • Caroline Thumerelle,
  • Stéphanie Lejeune,
  • Clémence Mordacq and
  • Philippe GossetEmail authorView ORCID ID profile
Respiratory Research201718:191
Abstract
Background
Viruses are important triggers of asthma exacerbations. They are also detected outside of exacerbation. Alteration of anti-viral response in asthmatic patients has been shown although the mechanisms responsible for this defect remain unclear. The objective of this study was to compare in virus-infected and not-infected allergic asthmatic children, aged 6 to 16 years, admitted to hospital for a severe exacerbation, the innate immune response and especially the expression of pattern recognition receptor (PRR) and their function.

Effect of an Intervention to Promote Breastfeeding on Asthma, Lung Function, and Atopic Eczema at Age 16 Years

Key Points
Question  Does prolonged and exclusive breastfeeding reduce the risk of asthma and atopic eczema and improve lung function in adolescence?

November 16, 2017

Extent and consequences of inadequate disease control among adults with a history of moderate to severe atopic dermatitis



Authors

  • Wenhui WeiPeter Anderson, Abhijit Gadkari, Stuart Blackburn, Rachel Moon, James Piercy, Shashank Shinde, Jorge Gomez, Eric Ghorayeb
  • DOI: 10.1111/1346-8138.14116  View/save citation
  • Abstract
    Since control of atopic dermatitis (AD) remains challenging but has not been adequately characterized, the objective of this study was to characterize disease control among patients with a history of moderate to severe AD.

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