|B. Bonnet, K. Messaoudi, F. Jacomet, E. Michaud, J. L. Fauquert, D. Caillaud and B. Evrard|
|Allergy, Asthma & Clinical Immunology 2018, 14:14 | Published on: 10 April 2018|
Cats are the major source of indoor inhalant allergens after house dust mites. The global incidence of cat allergies is rising sharply, posing a major public health problem. Ten cat allergens have been identified. The major allergen responsible for symptoms is Fel d 1, a secretoglobin and not a lipocalin, making the cat a special case among mammals.
Question Does use of medications that disturb the microbiome in infancy increase subsequent risk of developing allergic diseases?
Findings In this cohort study of 792 130 children, the hazard of developing an allergic disease was significantly increased in those who had received acid-suppressive medications or antibiotics during the first 6 months of life.
Meaning Exposure to acid-suppressive medications or antibiotics in the first 6 months of life may increase risk of allergic disease development.