April 22, 2017

Efficacy and safety of setipiprant in seasonal allergic rhinitis: results from Phase 2 and Phase 3 randomized, double-blind, placebo- and active-referenced studies

Allergy, Asthma & Clinical Immunology

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  • Paul RatnerEmail author,
  • Charles P. Andrews,
  • Frank C. Hampel,
  • Bruce Martin,
  • Dale E. Mohar,
  • Denis Bourrelly,
  • Parisa Danaietash,
  • Sara Mangialaio,
  • Jasper Dingemanse,
  • Abdel Hmissi and
  • Jay van Bavel

Abstract

Background
Antagonism of chemoattractant receptor-homologous molecule on T-helper type-2 cells (CRTH2), a G-protein coupled receptor for prostaglandin D2, could be beneficial for treating allergic disorders. We present findings on the efficacy and safety/tolerability of a CRTH2 antagonist (setipiprant) in participants with seasonal allergic rhinitis (AR) in a real-life setting over 2 weeks.

April 20, 2017

Effects of specific allergen immunotherapy on biological markers and clinical parameters in asthmatic children: a controlled-real life study

 
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  • I. Djuric-Filipovic,
  • Marco CaminatiEmail author,
  • D. Filipovic,
  • C. Salvottini and
  • Z. Zivkovic

Abstract
Background
Allergen-specific immunotherapy (AIT) is the only treatment able to change the natural course of allergic diseases. We aimed at investigating the clinical efficacy of SLITOR (Serbian registered vaccine for sublingual allergen specific immunotherapy).

April 19, 2017

The 2016 classification criteria for primary Sjogren’s syndrome: what’s new


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  • Franco Franceschini,
  • Ilaria CavazzanaEmail author,
  • Laura Andreoli and
  • Angela Tincani

Abstract
New 2016 ACR/EULAR classification criteria for primary Sjogren’s syndrome (SS) have been developed and endorsed by the ACR. The newly proposed criteria include simple-to-perform items.

April 14, 2017

Vitamin D deficiency and interleukin-17 relationship in severe obstructive sleep apnea–hypopnea syndrome

ORIGINAL ARTICLE
Year : 2017  |  Volume : 12  |  Issue : 2  |  Page : 107-113

1 Department of Basic Sciences, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia
2 Unit Research 12SP15 “Homeostasis and Cell Dysfunction”, Abderrahman Mami Hospital, Ariana, Tunisia


Correspondence Address:
Sonia Toujani
Department of Basic Sciences, Faculty of Medicine of Tunis, University of Tunis El Manar
Tunisia
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DOI: 10.4103/atm.ATM_301_16
   Abstract 
Purpose: We aimed to assess Vitamin D (VD) abnormalities in patients with severe obstructive sleep apnea–hypopnea syndrome (OSAHS), to study its association with clinical and polygraphic data, and to correlate VD levels with interleukin-17 (IL-17).
Methods: Ninety-two patients with severe OSAHS were consecutively enrolled between September 2014 and February 2016 and compared to age-, sex-, and body mass index (BMI)-matched controls. Anthropometric parameters and medical history were collected. The serum levels of VD and IL-17 were determined by radioimmunoassay and enzyme-linked immunosorbent assay, respectively.

Immunogenicity and safety of a quadrivalent inactivated influenza virus vaccine compared with a comparator quadrivalent inactivated influenza vaccine in a pediatric population: A phase 3, randomized noninferiority study

Available online 5 April 2017
  • Jolanta Aireya
  • Frank R. Albanoa
  • Daphne C. Sawlwinb
  • Alison Graves Jonesb
  • Neil Formicaa
  • Vince Matassaa
  • Jane Leongc
  •   Open Access

    Highlights

    First report of Seqirus IIV4 in children aged 5–17 years.
    Immunogenicity of Seqirus IIV4 was noninferior to a US-licensed comparator IIV4.
    Fever rates were similar for both vaccines in children 5–8 years and 9–17 years.

    Abstract
  • Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study

    Research
    Cite this as: BMJ 2017;357:j1415

    Akbar K Waljee, assistant professor1 2 3 4, Mary A M Rogers, research associate professor2 4 5, Paul Lin, statistican2,Amit G Singal, associate professor6, Joshua D Stein, associate professor2 7 8, Rory M Marks, associate professor 9,John Z Ayanian, professor2 5 8, Brahmajee K Nallamothu, professor 1 2 4 10
    Author affiliations
    Correspondence to: A K Waljee awaljee@med.umich.edu
    Abstract
    Objective To determine the frequency of prescriptions for short term use of oral corticosteroids, and adverse events (sepsis, venous thromboembolism, fractures) associated with their use.

    April 1, 2017

    Study of nasal exhaled nitric oxide levels in diagnosis of allergic rhinitis in subjects with and without asthma

    ORIGINAL RESEARCH


    Sy Duong-Quy,1–3 Thuc Vu-Minh,4 Thong Hua-Huy,1 Tram Tang-Thi-Thao,3 Khiet Le-Quang,3 Dinh Tran-Thanh,3 Nhu Doan-Thi-Quynh,3 Nhat-Nam Le-Dong,5 Timothy J Craig,2 Anh-Tuan Dinh-Xuan1

    1Department of Respiratory Physiology, Cochin Hospital, Paris Descartes University, Sorbonne Paris Cité, Paris, France; 2Department of Medicine, Penn State University, Hershey, PA, USA; 3Bio-Medical Research Center, Lam Dong Medical College, Dalat, 4Department of Immuno-Allergology, ENT National Institute, Hanoi, Vietnam; 5Department of Pulmonology, St Elisabeth Hospital, Namur, Belgium

    Background: The measure of fractional exhaled nitric oxide (FENO) in the airways is a useful tool to guide the diagnosis and titration of inhaled corticosteroids in patients with asthma. However, its role in diagnosis of allergic rhinitis (AR), especially in subjects with asthma, is not well established.
    Objective: To study the cutoff of nasal FENO in the diagnosis of subjects with AR and AR-asthma compared to age-matched subjects without AR or asthma and its correlations with the clinical and functional characteristics.

    March 29, 2017

    Japanese guidelines for allergic diseases 2017

    Allergists on Social Media