February 23, 2017

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data

BMJ 2017356 doi: https://doi.org/10.1136/bmj.i6583 (Published 15 February 2017)Cite this as: BMJ 2017;356:i6583
  • Adrian R Martineau, professor of respiratory infection and immunity2
  • David A Jolliffe, postdoctoral research fellow1
  • Richard L Hooper, reader in medical statistics1
  • Lauren Greenberg, medical statistician1
  • John F Aloia, professor of medicine3
  • Peter Bergman, associate professor4
  • Gal Dubnov-Raz, consultant paediatrician5
  • Susanna Esposito, professor of paediatrics6
  • Davaasambuu Ganmaa, assistant professor7
  • Adit A Ginde, professor of emergency medicine8
  • Emma C Goodall, assistant professor9
  • Cameron C Grant, associate professor10
  • Christopher J Griffiths, professor of primary care11
  • Wim Janssens, professor of pneumonology12
  • Ilkka Laaksi, chief administrative medical officer13
  • Semira Manaseki-Holland, senior clinical lecturer14
  • David Mauger, professor of public health sciences and statistics15
  • David R Murdoch, professor of pathology16
  • Rachel Neale, associate professor17
  • Judy R Rees, assistant professor18
  • Steve Simpson Jr, postdoctoral research fellow19
  • Iwona Stelmach, professor of paediatric allergy20
  • Geeta Trilok Kumar, associate professor21
  • Mitsuyoshi Urashima, professor of molecular epidemiology22
  • Carlos A Camargo Jr, professor of emergency medicine, medicine, and epidemiology23
    1. Author affiliations
    1. Correspondence to: A R Martineau a.martineau@qmul.ac.uk
    Objectives To assess the overall effect of vitamin D supplementation on risk of acute respiratory tract infection, and to identify factors modifying this effect.
    Design Systematic review and meta-analysis of individual participant data (IPD) from randomised controlled trials.

    February 15, 2017

    Self-assessment of Allergic Rhinitis and Asthma (SACRA) Questionnaire-based Allergic Rhinitis Treatment Improves Asthma Control in Asthmatic Patients with Allergic Rhinitis

    Internal Medicine
    Vol. 56 (2017) No. 1 p. 31-39


    Objective This study was conducted to investigate whether the add-on treatment of allergic rhinitis (AR) based on the Self-assessment of Allergic Rhinitis and Asthma (SACRA) questionnaire for assessing AR control improves both AR and asthma control in asthmatic patients with AR.
    Methods This multi-center prospective study was performed in Nagano prefecture, Japan. Two hundred five asthmatic patients and 23 respiratory physicians participated in the study. We administered add-on AR treatments based on the results of the SACRA questionnaire. After the first SACRA questionnaire, 67 asthmatic patients agreed to receive an add-on AR treatment. Three months after the AR treatment, a secondary SACRA questionnaire, asthma control test (ACT), and pulmonary function tests were performed.

    February 13, 2017

    Biomarkers for Monitoring Clinical Efficacy of Allergen Immunotherapy for Allergic Rhinoconjunctivitis and Allergic Asthma: an EAACI Position Paper.

     2017 Feb 2. doi: 10.1111/all.13138. [Epub ahead of print]


    Allergen immunotherapy (AIT) is an effective treatment for allergic rhinoconjunctivitis (AR) with or without asthma (1-12). AIT has disease modifying properties and confers long-term clinical benefit after cessation of treatment (6, 7, 13-17). AIT is routinely used in daily practice and can be administered either subcutaneously (SCIT) or sublingually (SLIT) (3-12).

    February 10, 2017

    High-dose anti-histamine use and risk factors in children with urticaria

    Pınar Uysal 1 ,  Sibelnur Avcil 2 ,  Duygu Erge 1 
    1 Adnan Menderes Üniversitesi Tıp Fakültesi, Çocuk Allerji ve Klinik İmmunoloji Bilim Dalı, Aydın, Türkiye 
    2 Adnan Menderes Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı, Aydın, Türkiye 

    Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria.

    February 9, 2017

    Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications

    • DOI: 10.1111/cea.12880View/save citation 
    • Summary
      Asthma is a complex respiratory disorder characterized by marked heterogeneity in individual patient disease triggers and response to therapy. Several asthma phenotypes have now been identified, each defined by a unique interaction between genetic and environmental factors, including inflammatory, clinical and trigger-related phenotypes.

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