January 18, 2018

The role of the gut microbiome in systemic inflammatory disease

State of the Art ReviewBMJ 2018360 doi: https://doi.org/10.1136/bmj.j5145 (Published 08 January 2018)Cite this as:  BMJ 2018;360:j51452018;360:j5145

    1. Jose C Clemente, assistant professor1,
    2. Julia Manasson, medical doctor2,
    3. Jose U Scher, assistant professor2
    Author affiliations
The role of the gut microbiome in models of inflammatory and autoimmune disease is now well characterized. Renewed interest in the human microbiome and its metabolites, as well as notable advances in host mucosal immunology, has opened multiple avenues of research to potentially modulate inflammatory responses.

Examining the association between maternal atopy and birth outcomes using a retrospective cohort in the southeastern region of the USA

Public health
Objective To assess birth outcomes in primiparous women with diagnosis of non-asthmatic atopy (NAA). Researchers hypothesised that women with NAA would have reduced the risk of adverse birth outcomes compared with women without NAA. NAA is defined as having allergic rhinitis and/or atopic dermatitis.

Setting Women were mostly treated in primary care settings in South Carolina, USA.

January 14, 2018

Reference values for spirometry in elderly individuals: a cross-sectional study of different reference equations

Open Access
  • Joana BeloEmail author,
  • Teresa Palmeiro,
  • Iolanda Caires,
  • Ana L. Papoila,
  • Marta Alves,
  • Pedro Carreiro-Martins,
  • Maria A. Botelho and
  • Nuno Neuparth
Multidisciplinary Respiratory Medicine201813:4
Spirometry is the single most important test for the evaluation of respiratory function. The results are interpreted by comparing measured data with predicted values previously obtained from a reference population. Reference equations for spirometry have been discussed previously.

January 13, 2018

The Diagnostic Accuracy of Fractional Exhaled Nitric Oxide Testing in Asthma: A Systematic Review and Meta-analyses

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January 10, 2018

Effect of air quality alerts on human health: a regression discontinuity analysis in Toronto, Canada

Open Access
Hong Chen, Qiongsi Li, MMath, Jay S Kaufman, PhD, Jun Wang, MSc, Ray Copes, MD, Yushan Su, PhD, Tarik Benmarhnia, PhD

Ambient air pollution is a major health risk globally. To reduce adverse health effects on days when air pollution is high, government agencies worldwide have implemented air quality alert programmes. Despite their widespread use, little is known about whether these programmes produce any observable public-health benefits. We assessed the effectiveness of such programmes using a quasi-experimental approach.

December 30, 2017

Recovery of hypothalamo–pituitary–adrenal axis suppression during treatment with inhaled corticosteroids for childhood asthma

Authors Gangadharan AMcCoy PPhyo A, McGuigan MP, Dharmaraj P, Ramakrishnan R, McNamara PS, Blair J
Published 15 December 2017 Journal of Asthma and Allergy Volume 2017:10 Pages 317—326
Objective: To describe recovery of adrenal insufficiency in asthmatic children treated with inhaled corticosteroids (ICS) and cortisol replacement therapy.

December 29, 2017

Case report: atypical presentation of vancomycin induced DRESS syndrome: a case report and review of the literature

Open Access
Open Peer Review
  • Olivia Wilcox,
  • Mohamed Hassanein,
  • John Armstrong and
  • Nader KassisEmail author
BMC Pulmonary MedicineBMC series – open, inclusive and trusted201717:217

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems.

December 27, 2017

Immunosenescence in aging: between immune cells depletion and cytokines up-regulation

 2017 Dec 14;15:21. doi: 10.1186/s12948-017-0077-0. eCollection 2017.


The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescence is the accumulation in the "immunological space" of memory and effector cells as a result of the stimulation caused by repeated clinical and subclinical infections and by continuous exposure to antigens (inhalant allergens, food, etc.).

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