Spotlight on dupilumab in the treatment of atopic dermatitis: design, development, and potential place in therapy

Drug Design, Development and Therapy. Volume 11

Angelo Massimiliano D’Erme,^1,2 Marco Romanelli,² Andrea Chiricozzi<sup>2

1</sup>Dermatology Unit, Livorno Hospital, Livorno, ²Dermatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

Abstract: Atopic dermatitis (AD) is among the most common inflammatory skin diseases in children and adults in industrialized countries. Up to one-third of adults (probably a smaller proportion in childhood) suffer from moderate-to-severe AD, whose recommended treatment is usually based on systemic therapies. The currently available therapeutics are limited, and AD management becomes challenging in most cases.

Searching online for health-related information by people suffering from respiratory allergy and asthma: the results of a survey study

Anna Kłak, Filip Raciborski, Bolesław Samoliński

DOI: 10.5603/ARM.2017.0015·Adv Respir Med 2017;85(2):87-96.

Abstract

INTRODUCTION:

The objective of the study was to compare online behaviour in groups of persons suffering from respiratory allergy and/or asthma and in the reference group.

Association of Oral Antireflux Medication With Laryngopharyngeal Reflux and Nasal Resistance

JAMA Otolaryngology

Original Investigation

May 2017

Elif Dagli, MD¹; Alper Yüksel, MD²; Mesut Kaya, MD²; et alKadriye Serife Ugur²; Fatma Cansel Turkay³

Author Affiliations

JAMA Otolaryngol Head Neck Surg. 2017;143(5):478-483. doi:10.1001/jamaoto.2016.4127

Key Points

Question  Is laryngopharyngeal reflux associated with nasal resistance, and does pharmacologic therapy improve subjective and objective nasal findings?

Findings  This case-control study of 100 adults (50 with laryngopharyngeal reflux, 50 controls) found that oral antireflux medication was associated with significant decreases in all parameters of the Nasal Obstruction Symptom Evaluation and Total Nasal Resistance values.

eHealth in the future of medications management: personalisation, monitoring and adherence

BMC Medicine 

OPINION

 

OPEN ACCESS

 

OPEN PEER REVIEW

• Josip CarEmail authorView ORCID ID profile,
• Woan Shin Tan,
• Zhilian Huang,
• Peter Sloot and
• Bryony Dean Franklin

BMC Medicine201715:73

DOI: 10.1186/s12916-017-0838-0

Abstract

Background

Globally, healthcare systems face major challenges with medicines management and medication adherence. Medication adherence determines medication effectiveness and can be the single most effective intervention for improving health outcomes.

Sensitization to Aspergillus species is associated with frequent exacerbations in severe asthma

ORIGINAL RESEARCH

Journal of Asthma and Allergy » Volume10

Ken Junyang Goh,¹ Anthony Chau Ang Yii,^1,2 Therese Sophie Lapperre,^1,2 Adrian KW Chan,^1–3 Fook Tim Chew,⁴ Sanjay H Chotirmall,^5,* Mariko Siyue Koh^1–3,*

¹Department of Respiratory and Critical Care Medicine, Singapore General Hospital, ²Duke-National University of Singapore Medical School, ³Allergy Centre, Singapore General Hospital, ⁴Department of Biological Sciences, Faculty of Science, National University of Singapore, ⁵Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore

*These authors contributed equally to this work

Background: Severe asthma is a largely heterogeneous disease with varying phenotypic profiles. The relationship between specific allergen sensitization and asthma severity, particularly in Asia, remains unclear. We aim to study the prevalence of specific allergen sensitization patterns and investigate their association with outcomes in a severe asthma cohort in an Asian setting.

Seasonal influenza vaccination in patients with COPD: a systematic literature review

BMC Pulmonary Medicine 

RESEARCH ARTICLE

 

OPEN ACCESS

 

OPEN PEER REVIEW

• Rafik Bekkat-BerkaniEmail author,
• Tom Wilkinson,
• Philippe Buchy,
• Gael Dos Santos,
• Dimitris Stefanidis,
• Jeanne-Marie Devaster and
• Nadia Meyer

BMC Pulmonary MedicineBMC series – open, inclusive and trusted201717:79

DOI: 10.1186/s12890-017-0420-8

Abstract

Background

Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD). Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life, disease progression, death, and ultimately, substantial healthcare-related costs. Despite longstanding recommendations to vaccinate vulnerable high-risk groups against seasonal influenza, including patients with COPD, vaccination rates remain sub-optimal in this population.

Pilot study of mobile phone technology in allergic rhinitis in European countries: the MASK-rhinitis study

Volume 72, Issue 6 June 2017 

• 1. 
     Previous article in issue: Overview of systematic reviews in allergy epidemiology
• 
  
• Abstract
  Background

  The use of Apps running on smartphones and tablets profoundly affects medicine. The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on patients’ lives. It is freely available in 20 countries (iOS and Android platforms).
  Aims

  
  

  To assess in a pilot study whether (i) Allergy Diary users were able to properly provide baseline characteristics (ii) simple phenotypic characteristics based upon data captured by the Allergy Diarycould be identified and (iii) information gathered by this study could suggest novel research questions.
  Methods

  The Allergy Diary users were classified into six groups according to the baseline data that they entered into the App: (i) asymptomatic; (ii) nasal symptoms excluding rhinorrhea; (iii) rhinorrhea; (iv) rhinorrhea plus 1–2 nasal/ocular symptoms; (v) rhinorrhea plus ≥3 nasal/ocular symptoms; and (vi) rhinorrhea plus all nasal/ocular symptoms.